HCID 22597833, compound → HCID 22597863, compound

HRID 1760251Notes

Reaction equation

HRID 1760251 reaction equation
[CH2:1]([O:3][C:4]1[CH:14]=[C:13]([CH:15]([CH3:17])[CH3:16])[C:12](Br)=[CH:11][C:5]=1[C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH3:2].[Cu][C:20]#[N:21]>CN1CCCC1=O>[CH2:1]([O:3][C:4]1[CH:14]=[C:13]([CH:15]([CH3:17])[CH3:16])[C:12]([C:20]#[N:21])=[CH:11][C:5]=1[C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH3:2]

Participants

4

Reactant 2

HCID 22597833HCID 22597833, compoundHCID 178418546HCID 178418546, compound

Product 1

HCID 22597863HCID 22597863, compoundYield 40.3%

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

Ethyl 2-ethoxy-4-iso-propyl-5-bromobenzoate (1.2 g, 3.8 mmol) was treated with copper (I) cyanide (682 mg, 7.6 mmol) in N-methyl-2-pyrrolidinone (40 ml) as described in Procedure 5 to give the title compound as an oil (400 mg).

Sources & evidence

ORD record
ord-13981f648bce4d5d910557a0f2b99d9f
Source dataset
uspto-grants-2005_01
Patent number
US06841560B2

Reaction notes

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