反应详情

A mixture of 1-[6-(4-vinyl-phenoxy)-pyridin-3-yl]-pyrrolidine-2,2-dicarboxylic acid diethyl ester (0.20 g), 50 mg of 10% palladium on charcoal and 20 mL of ethyl acetate was shaken under 50 psi of hydrogen gas for 2 hours. The mixture was filtered and concentrated in vacuo, affording 0.20 g of 1-[6-(4-ethyl-phenoxy)-pyridin-3-yl]-5-oxo-pyrrolidine-2,2-dicarboxylic acid diethyl ester as a colorless syrup. 1H NMR (CDCl3, 500 MHz): 8.08 (d, 1H, J=2.5 Hz), 7.73 (dd, 1H, J=2.5, 8.5 Hz), 7.24 (d, 2H, J=7.5 Hz), 7.05 (d, 2H, J=8.0 Hz), 6.89 (d, 1H, J=9.0 Hz), 4.21 (q, 4H, J=7.0 Hz), 2.74 (m, 2H), 2.65 (m, 4H), 1.27 (t, 3H, J=8.0 Hz), 1.20 (t, 6H, J=7.5 Hz) ppm.

1. filtrationThe mixture was filtered
2. concentrationconcentrated in vacuo