HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Mefenidil
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | HCID 15067816 | HCID 15067816 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Mefenidil | HCID 65475 | — |
Reaction Steps
A solution of 4-chloromethyl-5-methyl-2-phenylimidazole.HCl (40.5 g) in dimethylsulfoxide (400 ml) was added to a stirred solution of sodium cyanide (80 g) in dimethylsulfoxide (600 ml) over a period of 30 min. After 20 h the solids were filtered off, washed with water and dried in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06841553B2 |
| Source dataset | uspto-grants-2005_01 |
| ORD ID | ord-95bb055bc2cd4bc896855a0851b38b22 |
| Source note | uspto-grants-2005_01 |