反应详情

Hydrochloric acid in ethanol (35%, 150 ml) was added to 4-cyanomethyl-5-methyl-2-phenylimidazole (20.5 g) and heated to reflux temperature. After 1 h the reaction mixture was poured into water (400 ml) and NaOH was added (pH>8), followed by extraction with dichloromethane (3 times). The combined organic layers were dried over sodium sulfate and evaporated to dryness in vacuo.

1. temperatureheated
2. temperatureto reflux temperature
3. additionwas added (pH>8)
4. extractionfollowed by extraction with dichloromethane (3 times)
5. dry with materialThe combined organic layers were dried over sodium sulfate
6. customevaporated to dryness in vacuo