反应详情

A 250 mL three-neck round-bottom flask equipped with thermometer, magnetic stirring, and addition funnel was charged with a solution of 75 g of C4F9SO2NHCH3 in 80 g of dimethyl sulfoxide. The solution was stirred while a solution of 17.1 g potassium hydroxide in 20 g of water was added in 2 mL aliquots via pipette. The solution turned cloudy during the addition, then cleared with additional stirring. Allyl bromide (31.9 g) was charged to the addition funnel, and added dropwise to the reaction mixture. A rise in temperature of the reaction mixture to 75° C. was noted during the addition. The reaction mixture turned cloudy shortly after the addition was begun, and stirring was continued overnight at room temperature. The reaction mixture was poured into a separatory funnel and allowed to stand until the liquid layers had separated. A few mL water were added to the mixture to facilitate phase separation. The lower layer was drawn off, washed with water and brine, and dried over anhydrous magnesium sulfate, leaving 76.0 g of a clear, colorless crude liquid product which was vacuum distilled to yield 68.7 g C4F9SO2N(CH3)CH2CH═CH2, b.p. 97-101° C. at 19 torr (2.5 kPa).

1. customA 250 mL three-neck round-bottom flask equipped with thermometer, magnetic stirring, and addition funnel
2. additionwas added in 2 mL aliquots via pipette
3. additionThe solution turned cloudy during the addition
4. additionadded dropwise to the reaction mixture
5. additionA rise in temperature of the reaction mixture to 75° C. was noted during the addition
6. additionafter the addition
7. additionThe reaction mixture was poured into a separatory funnel
8. customhad separated
9. additionA few mL water were added to the mixture
10. customphase separation
11. washwashed with water and brine
12. dry with materialdried over anhydrous magnesium sulfate
13. customleaving 76.0 g of a clear, colorless crude liquid product which
14. distillationdistilled