Ethyl isobutyrylacetate → HCID 178439454, compound

HRID 1760535Notes

Reaction equation

HRID 1760535 reaction equation
Cl.[Cl:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([NH2:9])=[NH:8])=[CH:5][CH:4]=1.[CH3:12][CH:13]([CH3:22])[C:14](=O)[CH2:15][C:16](OCC)=[O:17].CC(C)([O-])C.[K+]>C(O)C>[Cl:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]2[N:9]=[C:16]([OH:17])[CH:15]=[C:14]([CH:13]([CH3:22])[CH3:12])[N:8]=2)=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 81583Ethyl isobutyrylacetateHCID 2034364-Chlorobenzene-1-carboximidamide hydrochlorideHCID 23665647Potassium tert-butoxide

Product 1

HCID 178439454HCID 178439454, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 19.1 g of 4-chlorobenzamidine hydrochloride, 15.8 g of ethyl 4-methyl-3-oxopentanoate, 11.2 g of potassium tert-butoxide and 200 ml of ethanol was heated under reflux for 2 hours. After cooling to room temperature, the solid was filtered off with suction, washed with water and with a little ethanol and dried at 40° C. in vacuo. Yield: 12.5 g. M.p.: 164° C.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 2 hours
  3. filtrationthe solid was filtered off with suction
  4. washwashed with water and with a little ethanol
  5. customdried at 40° C. in vacuo

Sources & evidence

ORD record
ord-9baea337a658411799a712625b99e8cc
Source dataset
uspto-grants-2005_01
Patent number
US06844347B1

Reaction notes

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