反应详情

A mixture of 19.1 g of 4-chlorobenzamidine hydrochloride, 15.8 g of ethyl 4-methyl-3-oxopentanoate, 11.2 g of potassium tert-butoxide and 200 ml of ethanol was heated under reflux for 2 hours. After cooling to room temperature, the solid was filtered off with suction, washed with water and with a little ethanol and dried at 40° C. in vacuo. Yield: 12.5 g. M.p.: 164° C.

1. temperaturewas heated
2. temperatureunder reflux for 2 hours
3. filtrationthe solid was filtered off with suction
4. washwashed with water and with a little ethanol
5. customdried at 40° C. in vacuo