反应详情

温度

90 °C

The mixture of 12 g of 2-(4-chlorophenyl)-4-hydroxy-6-isopropylpyrimidine and 35 ml of phosphorus oxychloride was heated at 90° C. for 3 hours with stirring. Most of the excess of the phosphorus oxychloride was distilled off in vacuo, and the residue was added to 100 ml of ice water and stirred. The solid white precipitate forming was filtered off with suction and dried in vacuo at room temperature.

1. distillationMost of the excess of the phosphorus oxychloride was distilled off in vacuo
2. additionthe residue was added to 100 ml of ice water
3. stirringstirred
4. customThe solid white precipitate forming
5. filtrationwas filtered off with suction
6. customdried in vacuo at room temperature