Phosphorus oxychloride → HCID 11471129, compound

HRID 1760536Notes

Reaction equation

HRID 1760536 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12](O)[CH:11]=[C:10]([CH:15]([CH3:17])[CH3:16])[N:9]=2)=[CH:4][CH:3]=1.P(Cl)(Cl)([Cl:20])=O>>[Cl:20][C:12]1[CH:11]=[C:10]([CH:15]([CH3:17])[CH3:16])[N:9]=[C:8]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)[N:13]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178439454HCID 178439454, compound

Product 1

HCID 11471129HCID 11471129, compound

Conditions

Temperature
90 °C

Procedure

The mixture of 12 g of 2-(4-chlorophenyl)-4-hydroxy-6-isopropylpyrimidine and 35 ml of phosphorus oxychloride was heated at 90° C. for 3 hours with stirring. Most of the excess of the phosphorus oxychloride was distilled off in vacuo, and the residue was added to 100 ml of ice water and stirred. The solid white precipitate forming was filtered off with suction and dried in vacuo at room temperature.

Workup

  1. distillationMost of the excess of the phosphorus oxychloride was distilled off in vacuo
  2. additionthe residue was added to 100 ml of ice water
  3. stirringstirred
  4. customThe solid white precipitate forming
  5. filtrationwas filtered off with suction
  6. customdried in vacuo at room temperature

Sources & evidence

ORD record
ord-51e927d439a745569a23caddef7ea23b
Source dataset
uspto-grants-2005_01
Patent number
US06844347B1

Reaction notes

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