Hydrogen Bromide → HCID 22596105, compound

HRID 1760547Notes

Reaction equation

HRID 1760547 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10]([CH2:17][CH2:18][CH2:19][CH2:20][N:21]3[CH2:26][CH2:25][C:24]4([C:34]5[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=5)[CH2:28][O:27]4)[CH2:23][CH2:22]3)=[CH:9]2)=[CH:4][CH:3]=1.[BrH:35]>>[BrH:35].[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10]([CH2:17][CH2:18][CH2:19][CH2:20][N:21]3[CH2:22][CH2:23][C:24]4([C:34]5[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=5)[CH2:28][O:27]4)[CH2:25][CH2:26]3)=[CH:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 9829526Siramesine

Product 1

HCID 22596105HCID 22596105, compound

Procedure

1′-[4-[1-(4-fluorophenyl)-1H-indole-3-yl]-1-butyl]-spiro[isobenzofuran-1(3H),4′-piperidine](1.05 g, oil) and 2-propanole (10 ml) was stirred and heated until the oil was dissolved. Aqueous hydrobromic acid (2.5 ml, 47% HBr) was added dropwise and a precipitate of the title compound was formed. More 2-propanole (5 ml) and hydrobromic acid (2.5 ml, 47% HBr) was added to the suspension. The suspension was cooled on ice and the precipitate was filtered off and dried.

Workup

  1. temperatureheated until the oil
  2. dissolutionwas dissolved

Sources & evidence

ORD record
ord-3dbc2717920a46d99e9858d7d2fca192
Source dataset
uspto-grants-2005_01
Patent number
US06844352B2

Reaction notes

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