反应详情

A mixture of 6-chloro-2,5-dimethylpyrimidin-4-yl-(2,4,6-trimethylphenyl)-acetonitrile (1.5 g, 5.0 mmol) and 60 ml of 85% phosphoric acid was heated at reflux for 2 hours. The mixture was cooled at rt and diluted with water and extracted with chloroform. The organic layer was washed with brine, dried and concentrated to give 1.21 g (95%) of the title compound as a white solid, mp 260-262° C.

1. temperaturewas heated
2. temperatureat reflux for 2 hours
3. extractionextracted with chloroform
4. washThe organic layer was washed with brine
5. customdried
6. concentrationconcentrated