Phosphoric Acid → 2,5-dimethyl-6-[(2,4,6-trimethylphenyl)methyl]-1H-pyrimidin-4-one

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Reaction Steps

A mixture of 6-chloro-2,5-dimethylpyrimidin-4-yl-(2,4,6-trimethylphenyl)-acetonitrile (1.5 g, 5.0 mmol) and 60 ml of 85% phosphoric acid was heated at reflux for 2 hours. The mixture was cooled at rt and diluted with water and extracted with chloroform. The organic layer was washed with brine, dried and concentrated to give 1.21 g (95%) of the title compound as a white solid, mp 260-262° C.

Provenance & Evidence