反应详情

To a solution of 4-Chloro-6-ethyl-3-methyl-2-(2,4,6-trimethyl-phenoxy)pyridine 1-oxide in methylene chloride was added PCl3 and the resulting mixture was heated at reflux for 20 min, cooled to rt. The mixture was concentrated to dryness. The residue was worked-up using standard procedure to give the title compound. After silica gel purification, the title compound was prepared as a white solid, mp. 42-44° C. Anal. For C17H20ClNO calc. C, 70.46; H, 6.96; N. 4.83; found, C, 70.35; H, 7.13; N, 4.58.

1. temperaturethe resulting mixture was heated
2. temperatureat reflux for 20 min
3. concentrationThe mixture was concentrated to dryness