Methylamine → HCID 135813645, compound

HRID 1760747Notes

Reaction equation

HRID 1760747 reaction equation
Cl[C:2]1[C:11]([N+:12]([O-:14])=[O:13])=[CH:10][CH:9]=[C:8]2[C:3]=1[C:4](=[O:15])[NH:5][CH:6]=[N:7]2.[CH3:16][NH2:17]>CO>[CH3:16][NH:17][C:2]1[C:11]([N+:12]([O-:14])=[O:13])=[CH:10][CH:9]=[C:8]2[C:3]=1[C:4](=[O:15])[NH:5][CH:6]=[N:7]2

Participants

4

Reactant 2

HCID 6329MethylamineHCID 135813639HCID 135813639, compound

Product 1

HCID 135813645HCID 135813645, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

5-Chloro-6-nitroquinazolin-4-one, from Example 3 (0.26 g, 1.15 mmol) was suspended in MeOH (3 mL) at −20° C. Methylamine gas was passed into the mixture for a few minutes, resulting in a clear solution. The solution was stirred at room temperature for 5 h and evaporated to give 5-methylamino-6-nitroquinazolin-4-one in quantitative yield.

Workup

  1. customresulting in a clear solution
  2. customevaporated

Sources & evidence

ORD record
ord-0f60a89da2bc48f38bd4771ceda8a9ff
Source dataset
uspto-grants-2005_01
Patent number
US06844435B2

Reaction notes

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