O-Methylhydroxylamine hydrochloride → HCID 59979521, compound

HRID 1760957Notes

Reaction equation

HRID 1760957 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C@H:9]([CH2:29][CH:30]=O)[CH2:10][N:11]2[C:17](=[O:18])[C:16]3[C:19]4[C:24]([CH:25]=[C:26]([C:27]#[N:28])[C:15]=3[S:14][CH2:13][CH2:12]2)=[CH:23][CH:22]=[CH:21][CH:20]=4)[CH:5]=[CH:6][C:7]=1[Cl:8].Cl.[CH3:33][O:34][NH2:35]>>[Cl:1][C:2]1[CH:3]=[C:4]([C@H:9]([CH2:29][CH2:30][NH:35][O:34][CH3:33])[CH2:10][N:11]2[C:17](=[O:18])[C:16]3[C:19]4[C:24]([CH:25]=[C:26]([C:27]#[N:28])[C:15]=3[S:14][CH2:13][CH2:12]2)=[CH:23][CH:22]=[CH:21][CH:20]=4)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

3

Reactant 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 59979507HCID 59979507, compound

Product 1

HCID 59979521HCID 59979521, compoundYield 65.8%

Procedure

By the method described in Example 79, Intermediate 78a (40 mg, 0.085 mmol) and methoxyamine hydrochloride (13 mg, 0.154 mmol) were converted to 28 mg of the title compound.

Sources & evidence

ORD record
ord-afcc9b65a675493382b0376107ad3270
Source dataset
uspto-grants-2005_01
Patent number
US06846814B2

Reaction notes

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