Trifluoroacetic acid → HCID 59979508, compound

HRID 1760958Notes

Reaction equation

HRID 1760958 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C@H:9]([CH2:29][CH:30]=O)[CH2:10][N:11]2[C:17](=[O:18])[C:16]3[C:19]4[C:24]([CH:25]=[C:26]([C:27]#[N:28])[C:15]=3[S:14][CH2:13][CH2:12]2)=[CH:23][CH:22]=[CH:21][CH:20]=4)[CH:5]=[CH:6][C:7]=1[Cl:8].[CH:32]1([NH2:35])[CH2:34][CH2:33]1.FC(F)(F)C(O)=O>>[Cl:1][C:2]1[CH:3]=[C:4]([C@H:9]([CH2:29][CH2:30][NH:35][CH:32]2[CH2:34][CH2:33]2)[CH2:10][N:11]2[C:17](=[O:18])[C:16]3[C:19]4[C:24]([CH:25]=[C:26]([C:27]#[N:28])[C:15]=3[S:14][CH2:13][CH2:12]2)=[CH:23][CH:22]=[CH:21][CH:20]=4)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 69828CyclopropylamineHCID 59979507HCID 59979507, compound

Product 1

HCID 59979508HCID 59979508, compoundYield 58.8%

Procedure

By the method described in Example 83, Intermediate 78a (70 mg, 0.15 mmol) and cyclopropylamine (13 mg, 0.23 mmol) were converted to 45 mg of the title compound as its trifluoroacetic acid salt.

Sources & evidence

ORD record
ord-b17fb721df0741b7a09bbe7c750ab0ff
Source dataset
uspto-grants-2005_01
Patent number
US06846814B2

Reaction notes

Loading…