反应详情

A mixture of 6-hydroxy-2,3-dihydro-isoindol-1-one (125.0 mg, 0.84 mmol) and 3-fluorobenzylbromide (174.3 mg, 0.92 mmol) in acetone (5 mL) containing potassium carbonate (276.4 mg, 2.0 mmol) was heated under reflux for 17 h. After cooling to RT the mixture was filtered and evaporated. The residue was purified by chromatography (SiO2, CH2Cl2:2N NH3-MeOH 90:10) to afford the title product (180 mg, 83%) as a white solid. MS m/e=258.2 (M+H+).

1. temperaturewas heated
2. temperatureunder reflux for 17 h
3. filtrationwas filtered
4. customevaporated
5. customThe residue was purified by chromatography (SiO2, CH2Cl2:2N NH3-MeOH 90:10)