Hydrochloric Acid → Methyl [4-(aminomethyl)-2,3-dihydro-1h-1-benzazepin-2-yl]acetate

Participants

Reaction Conditions

Reaction Steps

nBu4NBH4 is added at ambient temperature to a solution of the compound obtained in Step f (0.792 g; 2.34 mmol) in dichloroethane (10 ml). The reaction mixture is then heated at 45° C. for 8 hours. 10 ml of HCl (10%) are subsequently added and heating is carried out for 1 hour at 50° C. After concentration, the residue is chromatographed on silica (CH2Cl2/EtOH/NH4OH) to yield the title compound.

Provenance & Evidence