反应详情

温度

45 °C

nBu4NBH4 is added at ambient temperature to a solution of the compound obtained in Step f (0.792 g; 2.34 mmol) in dichloroethane (10 ml). The reaction mixture is then heated at 45° C. for 8 hours. 10 ml of HCl (10%) are subsequently added and heating is carried out for 1 hour at 50° C. After concentration, the residue is chromatographed on silica (CH2Cl2/EtOH/NH4OH) to yield the title compound.

1. temperatureheating
2. concentrationAfter concentration
3. customthe residue is chromatographed on silica (CH2Cl2/EtOH/NH4OH)