2H-Azepine, 3,4,5,6-tetrahydro-7-methoxy- → HCID 22594345, compound

HRID 1761032Notes

Reaction equation

HRID 1761032 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][NH2:12])=[O:7])([CH3:4])([CH3:3])[CH3:2].COC1[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]N=1>C(O)C>[N:12]1[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][C:11]=1[CH2:10][CH2:9][NH:8][C:6](=[O:7])[O:5][C:1]([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 756572H-Azepine, 3,4,5,6-tetrahydro-7-methoxy-HCID 2735700tert-Butyl (3-aminopropyl)carbamate

Product 1

HCID 22594345HCID 22594345, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A solution of N-tert-butoxycarbonyl-1,3-propanediamine (2 g; 11.48 mmol), described in Step a of Preparation A, in 1 ml of ethanol is added to a solution of 2-methoxy-4,5,6,7-tetrahydro-3H-azepine (1.46 g; 11.48 mmol; 1.7 ml) in 4 ml of absolute ethanol. After stirring for 8 hours at ambient temperature, the reaction mixture is concentrated to yield the expected product.

Workup

  1. customof Preparation A
  2. concentrationthe reaction mixture is concentrated

Sources & evidence

ORD record
ord-a5241cf35f094807beec0ed88599d8da
Source dataset
uspto-grants-2005_01
Patent number
US06846833B2

Reaction notes

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