反应详情

温度

75 °C

Methyl iodide (18 g; 127.4 mmol; 7.93 ml) is added at ambient temperature, under an argon atmosphere, to a solution of 3-[(aminocarbothioyl)amino]benzoic acid (25 g; 127.4 mmol) in 375 ml of anhydrous tetrahydrofuran, and then the reaction mixture is heated at 75° C. for 2 hours. After cooling and concentration, the residue is taken up in ether and the precipitate formed is filtered off to yield the expected product.

1. temperatureAfter cooling
2. concentrationconcentration
3. customthe precipitate formed
4. filtrationis filtered off