Methyl iodide → HCID 178503996, compound

HRID 1761033Notes

Reaction equation

HRID 1761033 reaction equation
[CH3:1]I.[NH2:3][C:4]([NH:6][C:7]1[CH:8]=[C:9]([CH:13]=[CH:14][CH:15]=1)[C:10]([OH:12])=[O:11])=[S:5]>O1CCCC1>[NH:3]=[C:4]([NH:6][C:7]1[CH:8]=[C:9]([CH:13]=[CH:14][CH:15]=1)[C:10]([OH:12])=[O:11])[S:5][CH3:1]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 8205751-(3-Carboxyphenyl)-2-thiourea

Product 1

HCID 178503996HCID 178503996, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
75 °C

Procedure

Methyl iodide (18 g; 127.4 mmol; 7.93 ml) is added at ambient temperature, under an argon atmosphere, to a solution of 3-[(aminocarbothioyl)amino]benzoic acid (25 g; 127.4 mmol) in 375 ml of anhydrous tetrahydrofuran, and then the reaction mixture is heated at 75° C. for 2 hours. After cooling and concentration, the residue is taken up in ether and the precipitate formed is filtered off to yield the expected product.

Workup

  1. temperatureAfter cooling
  2. concentrationconcentration
  3. customthe precipitate formed
  4. filtrationis filtered off

Sources & evidence

ORD record
ord-ff56684170c9424d8ca3e1bd96b8543d
Source dataset
uspto-grants-2005_01
Patent number
US06846833B2

Reaction notes

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