Hydrogen Bromide → 5-Bromo-3-(bromomethyl)pyridin-2-amine hydrobromide

HRID 1761061Notes

Reaction equation

HRID 1761061 reaction equation
[NH2:1][C:2]1[C:7]([CH2:8]O)=[CH:6][C:5]([Br:10])=[CH:4][N:3]=1.[BrH:11]>>[BrH:10].[NH2:1][C:2]1[C:7]([CH2:8][Br:11])=[CH:6][C:5]([Br:10])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 108913662-Amino-5-bromo-3-(hydroxymethyl)pyridine

Product 1

HCID 534200525-Bromo-3-(bromomethyl)pyridin-2-amine hydrobromide

Procedure

A solution of 2-amino-5-bromo-3-hydroxymethylpyridine (5.00 g. 24.6 mmole), from Preparation 14 (b), in 48% aqueous HBr (50 mL), was heated at reflux for 12 hrs. The reaction was concentrated and toluene was used to azeotrope the residual H2O. The resulting light brown solid was placed under high vacuum overnight and used directly.

Workup

  1. temperatureat reflux for 12 hrs
  2. concentrationThe reaction was concentrated
  3. customwas placed under high vacuum overnight

Sources & evidence

ORD record
ord-2eb185fff7c64e5aaa0c4167eeef6ec1
Source dataset
uspto-grants-2005_01
Patent number
US06846819B1

Reaction notes

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