反应详情

To a stirred solution of 1,3-dimethyl-2-(methylaminomethyl)-1H-indole (0.6 g, 3.2 mmole) in 1:1 DMF(CH2Cl2 (25 mL) was added (E)-3-(6aminopyridin-3-yl)acrylicacid (0.50 g, 3 mmole), HOBt H2O (0.43 g, 3.2 mmole), and DCC (0.66 g, 3.2 mmole). After stirring at RT for 16 hr the reaction was concentrated under vacuum. Purification by flash chromatography on silica gel (3% methanoUCHCl3) gave the title compound (0.83 g, 83%) as an off-white solid: LCMS (ES) n/e 335.4 (M+H)+.

1. concentrationwas concentrated under vacuum
2. customPurification by flash chromatography on silica gel (3% methanoUCHCl3)