HCID 69736348, compound → HCID 53901524, compound

HRID 1761134Notes

Reaction equation

HRID 1761134 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:9]=[C:10]2[C:14](=[CH:15][CH:16]=1)[NH:13][C:12](=[O:17])[C:11]2=[CH:18][C:19]1[NH:20][C:21]([CH2:26][CH3:27])=[CH:22][C:23]=1[CH2:24][CH3:25])(C)(C)C>FC(F)(F)C(O)=O.ClCCl>[NH2:7][C:8]1[CH:9]=[C:10]2[C:14](=[CH:15][CH:16]=1)[NH:13][C:12](=[O:17])[C:11]2=[CH:18][C:19]1[NH:20][C:21]([CH2:26][CH3:27])=[CH:22][C:23]=1[CH2:24][CH3:25]

Participants

4

Reactant 1

HCID 69736348HCID 69736348, compound

Product 1

HCID 53901524HCID 53901524, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

[3-(3,5-diethyl-1H-pyrrol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-5-yl]-carbamic acid tert-butyl ester in 50% trifluoroacetic acid in dichloromethane was stirred at room temperature for 2 hrs and concentrated. The red residue was suspended in saturated sodium bicarbonate solution. The precipitate was filtered, washed with water until pH 6 and dried overnight to give 5-amino-3-(3,5-diethyl-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one.

Workup

  1. concentrationconcentrated
  2. filtrationThe precipitate was filtered
  3. washwashed with water until pH 6
  4. customdried overnight

Sources & evidence

ORD record
ord-579526dd1b6645d6900bd571366f16a9
Source dataset
uspto-grants-2005_01
Patent number
US06846839B1

Reaction notes

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