Sodium sulfate decahydrate → (4R)-4-(2-Hydroxyethyl)-2,2-dimethyl-1,3-dioxolane

HRID 1761198Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1761198
[CH3:1][C:2]1([CH3:12])[O:6][C@H:5]([CH2:7][C:8](OC)=[O:9])[CH2:4][O:3]1.[H-].[Al+3].[Li+].[H-].[H-].[H-].O.O.O.O.O.O.O.O.O.O.S([O-])([O-])(=O)=O.[Na+].[Na+]>C(OCC)C>[CH3:1][C:2]1([CH3:12])[O:6][C@H:5]([CH2:7][CH2:8][OH:9])[CH2:4][O:3]1

Komponenten

5

Edukt 3

HCID 62649Sodium sulfate decahydrateHCID 11073901(R)-Methyl 2-(2,2-dimethyl-1,3-dioxolan-4-yl)acetateHCID 21226445Aluminium lithium hydride

Produkt 1

HCID 11480522(4R)-4-(2-Hydroxyethyl)-2,2-dimethyl-1,3-dioxolaneAusbeute 93,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

To a solution of 1.0 g of methyl 2-((4R)-2,2-dimethyl-1,3-dioxolan-4-yl)acetate in 29 ml of diethyl ether, 110 mg of lithium aluminum hydride was added under cooling with ice, followed by 12 hours' stirring at the same temperature. Sodium sulfate decahydrate was added to the reaction liquid which was then stirred for 30 minutes and filtered with Celite. Distilling the solvent off under reduced pressure, 782 mg of the title compound was obtained.

Aufarbeitung

  1. temperatureunder cooling with ice
  2. stirringwas then stirred for 30 minutes
  3. filtrationfiltered with Celite
  4. distillationDistilling the solvent off under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-a9747072b252487e96dcf6ab0fb13c4f
Quelldatensatz
uspto-grants-2005_01
Patentnummer
US06846835B2

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