Amlodipine → HCID 86591092, compound

HRID 1761246Notes

Reaction equation

[C:1]1([CH3:11])[CH:6]=[CH:5][C:4]([S:7]([OH:10])(=[O:9])=[O:8])=[CH:3][CH:2]=1.[CH3:12][CH2:13][O:14][C:15]([C:17]1[CH:22]([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][C:28]=2[Cl:29])[C:21]([C:30]([O:32][CH3:33])=[O:31])=[C:20]([CH3:34])[NH:19][C:18]=1[CH2:35][O:36][CH2:37][CH2:38][NH2:39])=[O:16]>CO>[CH3:12][CH2:13][O:14][C:15]([C:17]1[CH:22]([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][C:28]=2[Cl:29])[C:21]([C:30]([O:32][CH3:33])=[O:31])=[C:20]([CH3:34])[NH:19][C:18]=1[CH2:35][O:36][CH2:37][CH2:38][NH2:39])=[O:16].[C:1]1([CH3:11])[CH:2]=[CH:3][C:4]([S:7]([O-:10])(=[O:8])=[O:9])=[CH:5][CH:6]=1

Participants

Conditions

Temperature: 23 °C

Procedure

In 100 ml of methanol was dissolved 20 g of para-toluenesulfonic acid. To the solution, 40 g of the amlodipine prepared in Reference Example 1 in 500 ml of methanol was added dropwise, followed by stirring at 23° C. for 3 hours.

Workup

additionwas added dropwise

Sources & evidence

ORD record: ord-d1b6ee4db23c4ba3864cb49ee59e46bb
Source dataset: uspto-grants-2005_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06846931B2

Reaction notes

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