Hydrochloric Acid → 246852-07-3

HRID 1761247Notes

Reaction equation

HRID 1761247 reaction equation
[ClH:1].[CH3:2][CH2:3][O:4][C:5]([C:7]1[CH:12]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:18]=2[Cl:19])[C:11]([C:20]([O:22][CH3:23])=[O:21])=[C:10]([CH3:24])[NH:9][C:8]=1[CH2:25][O:26][CH2:27][CH2:28][NH2:29])=[O:6]>CO>[CH3:2][CH2:3][O:4][C:5]([C:7]1[CH:12]([C:13]2[C:18]([Cl:19])=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:11]([C:20]([O:22][CH3:23])=[O:21])=[C:10]([CH3:24])[NH:9][C:8]=1[CH2:25][O:26][CH2:27][CH2:28][NH2:29])=[O:6].[ClH:1]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 2162Amlodipine

Product 1

HCID 22228524246852-07-3

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Conditions

Temperature
23 °C

Procedure

To 100 ml of methanol was added 12 ml of conc-hydrochloric acid. 54 g of amlodipine prepared in Reference Example 1 in 500 ml of methanol was added dropwise, followed by stirring at 23° C. for 3 hours.

Workup

  1. additionwas added dropwise

Sources & evidence

ORD record
ord-e56e7a92bb974e789ce3bdbd08f50fe7
Source dataset
uspto-grants-2005_01
Patent number
US06846931B2

Reaction notes

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