Amlodipine → HCID 86593955, compound

HRID 1761248Notes

Reaction equation

HRID 1761248 reaction equation
[CH3:1][CH2:2][O:3][C:4]([C:6]1[CH:11]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:17]=2[Cl:18])[C:10]([C:19]([O:21][CH3:22])=[O:20])=[C:9]([CH3:23])[NH:8][C:7]=1[CH2:24][O:25][CH2:26][CH2:27][NH2:28])=[O:5].[NH:29]1[C:33](=[O:34])[CH2:32][CH2:31][C@H:30]1[C:35]([OH:37])=[O:36]>C(OCC)(=O)C>[CH3:1][CH2:2][O:3][C:4]([C:6]1[CH:11]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:17]=2[Cl:18])[C:10]([C:19]([O:21][CH3:22])=[O:20])=[C:9]([CH3:23])[NH:8][C:7]=1[CH2:24][O:25][CH2:26][CH2:27][NH2:28])=[O:5].[NH:29]1[C:33](=[O:34])[CH2:32][CH2:31][C@H:30]1[C:35]([O-:37])=[O:36]

Participants

4

Reactant 2

HCID 2162AmlodipineHCID 7405L-Pyroglutamic Acid

Product 1

HCID 86593955HCID 86593955, compoundYield 95.5%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Amlodipine (10g, 0.025 mole) was dissolved in ethyl acetate (100 ml) with stirring. The solution was adjusted to 25° C. and slowly added with (S)-(−)-pyroglutamic acid (3.61g, 0.028 mole). This reaction was stirred at 25° C. for 1 hour to produce precipitates. They were filtered off and washed with ethyl acetate (50 ml), followed by drying at 40° C. under vacuum to give 12.82 g of the title compound (Yield 95.3%).

Workup

  1. customwas adjusted to 25° C.
  2. stirringThis reaction was stirred at 25° C. for 1 hour
  3. customto produce
  4. customprecipitates
  5. filtrationThey were filtered off
  6. washwashed with ethyl acetate (50 ml)
  7. customby drying at 40° C. under vacuum

Sources & evidence

ORD record
ord-01a01c6ddae54f11b1d3ad2b7eb3cc7a
Source dataset
uspto-grants-2005_01
Patent number
US06846931B2

Reaction notes

Loading…