Tetramethoxypropane → Pyrido[2,3-d]pyrimidin-2-amine, 4-chloro-

HRID 1761319Notes

Reaction equation

HRID 1761319 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4]([NH2:9])[N:3]=1.CO[CH:12](OC)[CH2:13][CH:14](OC)OC>>[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[C:5]2[CH:14]=[CH:13][CH:12]=[N:9][C:4]=2[N:3]=1

Participants

3

Reactant 2

HCID 66019TetramethoxypropaneHCID 674322,4-Diamino-6-chloropyrimidine

Product 1

HCID 20043933Pyrido[2,3-d]pyrimidin-2-amine, 4-chloro-

Procedure

Starting from 2,6-diamino-4-chloropyrimidine and 1,1,3,3-tetramethoxypropane and using a procedure analogous to that of Example 71, the above compound is isolated after chromatographic purification on silica gel with methanol/diisopropylether (1:1) as a yellow oil which can be used in the following reactions without any further purification.

Workup

  1. customthe above compound is isolated
  2. customafter chromatographic purification on silica gel with methanol/diisopropylether (1:1) as a yellow oil which
  3. customcan be used in the following reactions without any further purification

Sources & evidence

ORD record
ord-64b68a6731894e339d2dfaf406409927
Source dataset
uspto-grants-1989_05
Patent number
US04826528

Reaction notes

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