Tetramethoxypropane → 2-Amino-4-chloro-pyrido[2,3-d]pyrimidine

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Reaction Steps

Starting from 2,6-diamino-4-chloropyrimidine and 1,1,3,3-tetramethoxypropane and using a procedure analogous to that of Example 71, the above compound is isolated after chromatographic purification on silica gel with methanol/diisopropylether (1:1) as a yellow oil which can be used in the following reactions without any further purification.

Provenance & Evidence