Phosphorus sulfide (P2S5) → HCID 178509028, compound

HRID 1761320Notes

Reaction equation

HRID 1761320 reaction equation
[NH2:1][C:2]1[N:3]=[C:4](O)[C:5]2[CH:11]=[CH:10][CH:9]=[N:8][C:6]=2[N:7]=1.P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:14]>N1C=CC=CC=1>[NH2:1][C:2]1[N:3]=[C:4]([SH:14])[C:5]2[CH:11]=[CH:10][CH:9]=[N:8][C:6]=2[N:7]=1

Participants

4

Reactant 2

HCID 14817Phosphorus sulfide (P2S5)HCID 178508858HCID 178508858, compound

Product 1

HCID 178509028HCID 178509028, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

2-Amino-4-hydroxypyrido[2,3-d]pyrimidine (8.1 gm) is heated to boiling for ten hours with phosphorus pentasulfide (25 gm) in pyridine (125 ml). After the solvent has been distilled off, the residue is triturated with water, made alkaline with sodium hydroxide solution, and purified with activated charcoal, and the filtrate is acidified with acetic acid. The yellow fine crystalline powder precipitate is washed with water and dried.

Workup

  1. distillationAfter the solvent has been distilled off
  2. customthe residue is triturated with water
  3. custompurified with activated charcoal
  4. washThe yellow fine crystalline powder precipitate is washed with water
  5. customdried

Sources & evidence

ORD record
ord-2b988e2fa5734892ad9ba0808a536630
Source dataset
uspto-grants-1989_05
Patent number
US04826528

Reaction notes

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