Phosphorus sulfide (P2S5) → HCID 178509028, compound

Participants

Reaction Steps

2-Amino-4-hydroxypyrido[2,3-d]pyrimidine (8.1 gm) is heated to boiling for ten hours with phosphorus pentasulfide (25 gm) in pyridine (125 ml). After the solvent has been distilled off, the residue is triturated with water, made alkaline with sodium hydroxide solution, and purified with activated charcoal, and the filtrate is acidified with acetic acid. The yellow fine crystalline powder precipitate is washed with water and dried.

Provenance & Evidence