Chloroform → HCID 20044191, compound

HRID 1761363Notes

Reaction equation

HRID 1761363 reaction equation
[N:1]([CH2:4][CH:5]([OH:19])[CH:6]([NH:11][C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:7][CH:8]([CH3:10])[CH3:9])=[N+]=[N-].C(Cl)(Cl)[Cl:21].[H][H]>CO.[Pd]>[ClH:21].[NH2:1][CH2:4][CH:5]([OH:19])[CH:6]([NH:11][C:12]([O:14][C:15]([CH3:16])([CH3:18])[CH3:17])=[O:13])[CH2:7][CH:8]([CH3:10])[CH3:9]

Participants

6

Reactant 3

HCID 6212ChloroformHCID 13985405HCID 13985405, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20044191HCID 20044191, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The resultant compound of Example 75 (400 mg) dissolved in methanol containing added CHCl3 was hydrogenated over 10% Pd/C (40mg) with 3 atmospheres hydrogen. Filtration and evaporation gave the desired compound (305mg).

Workup

  1. filtrationFiltration and evaporation

Sources & evidence

ORD record
ord-a4f8f501a0254fea8f20ad53cae932f5
Source dataset
uspto-grants-1989_05
Patent number
US04826815

Reaction notes

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