Triethylamine → HCID 20044184, compound

HRID 1761364Notes

Reaction equation

HRID 1761364 reaction equation
Cl.[NH2:2][CH2:3][CH:4]([OH:18])[CH:5]([NH:10][C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:6][CH:7]([CH3:9])[CH3:8].C(N(CC)CC)C.[C:26](Cl)(=[O:31])[CH2:27][CH:28]([CH3:30])[CH3:29]>C(Cl)(Cl)Cl>[C:14]([O:13][C:11]([NH:10][CH:5]([CH2:6][CH:7]([CH3:9])[CH3:8])[CH:4]([OH:18])[CH2:3][NH:2][C:26](=[O:31])[CH2:27][CH:28]([CH3:30])[CH3:29])=[O:12])([CH3:16])([CH3:15])[CH3:17]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 66054Isovaleryl chlorideHCID 20044191HCID 20044191, compound

Product 1

HCID 20044184HCID 20044184, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

To a solution of the resultant compound of Example 76 (1.0 mmol) and triethyl amine (2.0 mmol) in chloroform (10ml) cooled to 0° C. was added isovaleryl chloride (1.0 mmol) in CHCl3 (2ml). After 3h, the solution was washed sequentially with 10% citric acid, saturated NaHCO3, and brine. Drying and evaporating provided the desired compound.

Workup

  1. washAfter 3h, the solution was washed sequentially with 10% citric acid, saturated NaHCO3, and brine
  2. customDrying
  3. customevaporating

Sources & evidence

ORD record
ord-362754de0e424283ba754968c0257584
Source dataset
uspto-grants-1989_05
Patent number
US04826815

Reaction notes

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