Trifluoroacetic acid → HCID 15631243, compound

HRID 1761366Notes

Reaction equation

HRID 1761366 reaction equation
C([CH2:5][C:6]([C@@H:8]([CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:9]([O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:10])=[O:7])(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[CH2:12]([O:11][C:9](=[O:10])[C@@H:8]([C:6](=[O:7])[CH3:5])[CH2:19][C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 15631241HCID 15631241, compound

Product 1

HCID 15631243HCID 15631243, compoundYield 105.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The product from Example 94 (0.52 g, 1.47 mmol) was dissolved in a 1:1 (v:v) solution (6 mL). of trifluoroacetic acid and dichloromethane and stirred at room temperature for 1 h. The volatiles were removed in vacuo to provide the title compound (0.437 g, 100%) as an oil which crystallized on standing. The unpurified material was of sufficient purity to employ in subsequent steps. Mass spectrum: (M)+=298.

Workup

  1. customThe volatiles were removed in vacuo

Sources & evidence

ORD record
ord-a8ed8fe632c846ad90476439c36926d5
Source dataset
uspto-grants-1989_05
Patent number
US04826815

Reaction notes

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