Hydrochloric Acid → HCID 86742968, compound

HRID 1761369Notes

Reaction equation

HRID 1761369 reaction equation
C[O:2][C:3](=[O:24])[C@:4]([N:17]([CH2:19][CH:20]([OH:23])[CH2:21][OH:22])[CH3:18])([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=1)[N:5]=[C:6]=[O:7].Cl>O1CCOCC1.O>[CH3:18][N:17]([C@@:4]([C:3]([OH:24])=[O:2])([CH2:8][C:9]1[CH:10]=[CH:11][C:12]([O:15][CH3:16])=[CH:13][CH:14]=1)[N:5]=[C:6]=[O:7])[CH2:19][CH:20]([OH:23])[CH2:21][OH:22]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 54305480HCID 54305480, compound

Product 1

HCID 86742968HCID 86742968, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

The resultant compound from Example 115 (114 mg, 0.355 mmol) in dioxane (4 ml) and water (2 ml) at 0° C. was treated with LiOH monohydrate (42.0 mg, 1 mmol). After 90 min 2M HCl (0.6 ml, 1.2 mmol) was added and the mixture was evaporated to a form which was used without further purification; DCI-MS: (M+H)+ =327.

Workup

  1. customthe mixture was evaporated to a form which
  2. customwas used without further purification

Sources & evidence

ORD record
ord-071184b19ab14ab184ef3d5d0bae11b4
Source dataset
uspto-grants-1989_05
Patent number
US04826815

Reaction notes

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