Saccharin → HCID 14303123, compound

Participants

Reaction Steps

4.85 g (0.012 mol) of 2-[2-(3-trifluoromethylphenoxy)-prop-2-yl]-2-methyl-4-(piperidin-1-yl-methyl)-1,3-dioxolane are dissolved in 50 ml of ethanol together with 2.17 g (0.012 mol) of saccharine. The clear solution is evaporated in vacuo and the residue is dried under a high vacuum. 7 g (100% of theory) of 2-[2-(3-trifluoromethyl-phenoxy)-prop-2-yl]-2-methyl-4-(piperidin-1-yl-methyl)-1,3-dioxolane saccharine salt are obtained as an amorphous compound.

Provenance & Evidence