Saccharin → HCID 14303123, compound

HRID 1761383Notes

Reaction equation

HRID 1761383 reaction equation
[F:1][C:2]([F:27])([F:26])[C:3]1[CH:4]=[C:5]([CH:23]=[CH:24][CH:25]=1)[O:6][C:7]([C:10]1([CH3:22])[O:14][CH:13]([CH2:15][N:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)[CH2:12][O:11]1)([CH3:9])[CH3:8].[S:28]1([C:39]2[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=2)[C:32](=[O:33])[NH:31]1)(=[O:30])=[O:29]>C(O)C>[S:28]1([C:39]2[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=2)[C:32](=[O:33])[NH:31]1)(=[O:29])=[O:30].[F:26][C:2]([F:1])([F:27])[C:3]1[CH:4]=[C:5]([CH:23]=[CH:24][CH:25]=1)[O:6][C:7]([C:10]1([CH3:22])[O:14][CH:13]([CH2:15][N:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)[CH2:12][O:11]1)([CH3:9])[CH3:8]

Participants

4

Reactant 2

HCID 5143SaccharinHCID 14303121HCID 14303121, compound

Product 1

HCID 14303123HCID 14303123, compoundYield 102.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4.85 g (0.012 mol) of 2-[2-(3-trifluoromethylphenoxy)-prop-2-yl]-2-methyl-4-(piperidin-1-yl-methyl)-1,3-dioxolane are dissolved in 50 ml of ethanol together with 2.17 g (0.012 mol) of saccharine. The clear solution is evaporated in vacuo and the residue is dried under a high vacuum. 7 g (100% of theory) of 2-[2-(3-trifluoromethyl-phenoxy)-prop-2-yl]-2-methyl-4-(piperidin-1-yl-methyl)-1,3-dioxolane saccharine salt are obtained as an amorphous compound.

Workup

  1. customThe clear solution is evaporated in vacuo
  2. customthe residue is dried under a high vacuum

Sources & evidence

ORD record
ord-ffb80cef9c0e4a0f8f6bd91fc561c9b6
Source dataset
uspto-grants-1989_05
Patent number
US04826836

Reaction notes

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