HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[(3S,4R)-3-[(1R)-1-allyloxycarbonyloxyethyl]-4-mercapto-2-oxo-azetidin-1-yl]-2-triphenylphosphoranylideneacetic acid allyl ester → 2-[(3S,4R)-3-[(1R)-1-allyloxycarbonyloxyethyl]-4-(6-methylnicotinoylthio)-2-oxo-azetidin-1-yl]-2-triphenylphosphoranylideneacetic acid allyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[(3S,4R)-3-[(1R)-1-allyloxycarbonyloxyethyl]-4-mercapto-2-oxo-azetidin-1-yl]-2-triphenylphosphoranylideneacetic acid allyl ester | HCID 14084562 | — |
| Reactant | 6-Methylnicotinoyl chloride hydrochloride | HCID 22721631 | — |
| Catalyst | Silver | HCID 23954 | — |
| Product | 2-[(3S,4R)-3-[(1R)-1-allyloxycarbonyloxyethyl]-4-(6-methylnicotinoylthio)-2-oxo-azetidin-1-yl]-2-triphenylphosphoranylideneacetic acid allyl ester | HCID 56986149 | — |
Reaction Steps
0.415 g of the silver salt of 2-[(3S,4R)-3-[(1R)-1-allyloxycarbonyloxyethyl]-4-mercapto-2-oxo-azetidin-1-yl]-2-triphenylphosphoranylideneacetic acid allyl ester and 0.18 g of 6-methylnicotinoyl chloride hydrochloride are converted into the title compound analogously to Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04826832 |
| Source dataset | uspto-grants-1989_05 |
| ORD ID | ord-bb5b86a0397045419c2361614eb4cf94 |
| Source note | uspto-grants-1989_05 |