Water → N-Benzyl-1,3-benzothiazol-2-amine

HRID 1761459Notes

Reaction equation

HRID 1761459 reaction equation
[C:1]1([NH:7][C:8]([NH:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[S:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.BrBr.O.[OH-].[NH4+]>C(O)(=O)C>[CH2:11]([NH:10][C:8]1[S:9][C:6]2[CH:5]=[CH:4][CH:3]=[CH:2][C:1]=2[N:7]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

6

Reactant 4

HCID 962WaterHCID 14923Ammonium HydroxideHCID 24408BromineHCID 6683001-Benzyl-3-phenyl-2-thiourea

Product 1

HCID 617555N-Benzyl-1,3-benzothiazol-2-amine

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

To a stirred solution of 12.1 g (0.05 mol) of N-phenyl-N'-benzylthiourea in 150 ml of glacial acetic acid was added dropwise 8.0 g (0.05 mol) of bromine in 60 mL of glacial acetic acid. The reaction was poured into 10 volumes of water and made basic with concentrated ammonium hydroxide. A solid precipitated from the aqueous solution and was filtered. The solid could be recrystallized from an appropriate solvent to yield N-benzyl-2-benzothiazolamine.

Workup

  1. customA solid precipitated from the aqueous solution
  2. filtrationwas filtered
  3. customThe solid could be recrystallized from an appropriate solvent

Sources & evidence

ORD record
ord-8bf5c1de55b0435a8daef964808c369d
Source dataset
uspto-grants-1989_05
Patent number
US04826860

Reaction notes

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