Diethylamine → HCID 86742971, compound

Participants

Reaction Steps

One millimole of 9,10-didehydro-1,6-dimethylergoline-8α-amine is reacted with 1,1'-thiocarbonyldiimidazole and diethylamine, as described in Example 11, to 3-(9,10-didehydro-1,6-dimethyl-8α-ergolinyl)-1,1-diethylthioruea. After chromatography, 3-(9,10-didehydro-1,6-dimethyl-8α-ergolinyl)-1,1-diethylthiourea is obtained in a 67% yield. By dissolution with the equivalent quantity of L-tartaric acid in methylene chloride and methanol, 3-(9,10-didehydro-1,6-dimethyl-8α-ergolinyl)-1,1-diethylthiourea tartrate is obtained.

Provenance & Evidence