反应详情

To a stirred and cooled (-10° C.) mixture of 41.6 parts of N,N'-methanetetraylbis[cyclohexanamine], 101 parts of carbon disulfide and 450 parts of tetrahydrofuran was added dropwise a solution of 31.2 parts of 1-acetyl-4-piperidinmethanamine in 90 parts of tetrahydrofuran. Upon completion, stirring was continued overnight at room temperature. The reaction mixture was evaporated, 2,2'-Oxybispropane was added to the residue. The precipitate was filtered off and the filtrate was evaporated, yielding 40 parts (100%) of 1-acetyl-4-(isothiocyanatomethyl) piperidine as a residue (intermediate 10).

1. temperaturecooled
2. stirringUpon completion, stirring
3. customThe reaction mixture was evaporated
4. addition2,2'-Oxybispropane was added to the residue
5. filtrationThe precipitate was filtered off
6. customthe filtrate was evaporated