Thiophene → HCID 14500562, compound

HRID 1761512Notes

Reaction equation

HRID 1761512 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([N:19]2[CH:23]=[CH:22][N:21]=[CH:20]2)[C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[C:11]([N+:16]([O-])=O)[CH:10]=2)=[CH:4][CH:3]=1.S1C=CC=C1.[H][H]>CO.[Pt]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([N:19]2[CH:23]=[CH:22][N:21]=[CH:20]2)[C:9]2[CH:10]=[C:11]([NH2:16])[C:12]([NH2:15])=[CH:13][CH:14]=2)=[CH:6][CH:7]=1

Participants

6

Reactant 3

HCID 8030ThiopheneHCID 14500561HCID 14500561, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 14500562HCID 14500562, compound

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 887MethanolSolvent2×

Procedure

A mixture of 6.24 parts of 4-[(4-fluorophenyl)(1H-imidazol-1-yl)methyl]-2-nitrobenzenamine, 1 part of a solution of thiophene in methanol 4% and 200 parts of methanol was hydrogenated at normal pressure and at room temperature with 2 parts of platinum-on-charcoal catalyst 5%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated, yielding 5.6 parts of 4-[(4-fluorophenyl)(1H-imidazol-1-yl)methyl]-1,2-benzenediamine as a residue (int. 5).

Workup

  1. filtrationthe catalyst was filtered off
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-117aaa33556b4d239b88e4086e06c20f
Source dataset
uspto-grants-1989_05
Patent number
US04826862

Reaction notes

Loading…