Acetic Anhydride → N-(3-Chloro-4-fluorophenyl)acetamide

HRID 1761640Notes

Reaction equation

HRID 1761640 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[F:9])[NH2:5].[C:10](OC(=O)C)(=[O:12])[CH3:11]>O>[Cl:1][C:2]1[CH:3]=[C:4]([NH:5][C:10](=[O:12])[CH3:11])[CH:6]=[CH:7][C:8]=1[F:9]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 97083-Chloro-4-fluoroaniline

Product 1

HCID 589188N-(3-Chloro-4-fluorophenyl)acetamide

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 3-chloro-4-fluoroaniline (100 g) was slowly added acetic anhydride (200 ml). After allowed to stand for 30 minutes, the reaction mixture was poured into water (1 litter). The resulting precipitate was collected by filtration and recrystallized from aqueous ethanol to give the title compound (119.4 g), mp 118°-119° C.

Workup

  1. filtrationThe resulting precipitate was collected by filtration
  2. customrecrystallized from aqueous ethanol

Sources & evidence

ORD record
ord-5e5001753cee4cfdbeb924443d6973e6
Source dataset
uspto-grants-1989_05
Patent number
US04826982

Reaction notes

Loading…