Thionyl Chloride → 3-Bromo-2,4,5-trifluorobenzoyl chloride

HRID 1761648Notes

Reaction equation

HRID 1761648 reaction equation
[Br:1][C:2]1[C:3]([F:13])=[C:4]([CH:8]=[C:9]([F:12])[C:10]=1[F:11])[C:5](O)=[O:6].S(Cl)([Cl:16])=O>>[Br:1][C:2]1[C:3]([F:13])=[C:4]([CH:8]=[C:9]([F:12])[C:10]=1[F:11])[C:5]([Cl:16])=[O:6]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 27832463-Bromo-2,4,5-trifluorobenzoic acid

Product 1

HCID 137488023-Bromo-2,4,5-trifluorobenzoyl chloride

Procedure

A solution of the 3-bromo-2,4,5-trifluorobenzoic acid (2.5 g) in thionyl chloride (10 ml) was refluxed for 2.5 hours, and then concentrated. The resulting residue was purified by distillation through Widmer fractionating column to give the title compound (2.3 g), bp 98°-102° C./18 mmHg.

Workup

  1. concentrationconcentrated
  2. distillationThe resulting residue was purified by distillation through Widmer fractionating column

Sources & evidence

ORD record
ord-e7c2bcbdd9f2453ebd6e159b46ed4b38
Source dataset
uspto-grants-1989_05
Patent number
US04826982

Reaction notes

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