Hydrochloric Acid → HCID 10997097, compound

HRID 1761722Notes

Reaction equation

HRID 1761722 reaction equation
[CH2:1]([N:4]([C:9]([O:11]C)=O)[C:5](=O)[CH2:6][NH2:7])[C:2]#[CH:3].[OH-:13].[Na+].Cl>CO>[CH2:1]([N:4]1[CH2:5][C:6](=[O:13])[NH:7][C:9]1=[O:11])[C:2]#[CH:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 21242407HCID 21242407, compound

Product 1

HCID 10997097HCID 10997097, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
70 °C

Procedure

2.0 g of N-propargyl-N-methoxycarbonylglycinamide were added to the mixture of 5 ml of methanol and 2.5 ml of 20% aqueous solution of sodium hydroxide and maintained at 70° C. for an hour. After cooled down to room temperature; the reaction mixture was neutralized with concentrated hydrochloric acid followed by concentrating and drying the same by an evaporation under reduced pressure. Then it was extracted with acetonitrile and sodium chloride was removed off from the extract by filtration. The solvent was evaporated off from the filtrate to obtain 1.4 g of 1-propargyl-2,4-dioxoimidazolidine (melting point: 124°-125° C.).

Workup

  1. temperatureAfter cooled down to room temperature
  2. concentrationby concentrating
  3. customdrying the
  4. customsame by an evaporation under reduced pressure
  5. extractionThen it was extracted with acetonitrile and sodium chloride
  6. customwas removed off from the
  7. extractionextract by filtration
  8. customThe solvent was evaporated off from the filtrate

Sources & evidence

ORD record
ord-f05c517ad5bc4a8baf1a6ee67ce0ad6f
Source dataset
uspto-grants-1989_05
Patent number
US04827020

Reaction notes

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