1H-1,2,4-Triazole → HCID 13650454, compound

Participants

Reaction Steps

44.7 g (0.648 mol) of 1,2,4-triazole and 89.5 g (0.648 mol) of anhydrous potassium carbonate were suspended in 525 ml of acetonitrile, and, under reflux, 202 g (0.6 mol) of of acetonitrile, and, under reflux, 202 g (0.6 mol) of 1-bromo-3-chloropropyl 4-phenylphenyl ketone were added in portions over 20 minutes. After a reaction time of 3 hours under reflux, the mixture was poured into ice water and the crystals obtained were filtered off under suction. 162.0 g (93% of theory) of colorless crystals of melting point 154°-5° C. were obtained.

Provenance & Evidence