1H-1,2,4-Triazole → HCID 13650454, compound

HRID 1761889Notes

Reaction equation

HRID 1761889 reaction equation
[NH:1]1[CH:5]=[N:4][CH:3]=[N:2]1.C(=O)([O-])[O-].[K+].[K+].[C:12]1([C:18]2[CH:23]=[CH:22][C:21]([C:24]([CH:26](Br)[CH2:27][CH2:28]Cl)=[O:25])=[CH:20][CH:19]=2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C(#N)C>[N:1]1([C:26]2([C:24]([C:21]3[CH:22]=[CH:23][C:18]([C:12]4[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=4)=[CH:19][CH:20]=3)=[O:25])[CH2:28][CH2:27]2)[CH:5]=[N:4][CH:3]=[N:2]1

Participants

5

Reactant 3

HCID 92571H-1,2,4-TriazoleHCID 11430Potassium CarbonateHCID 14125892HCID 14125892, compound

Product 1

HCID 13650454HCID 13650454, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent2×

Procedure

44.7 g (0.648 mol) of 1,2,4-triazole and 89.5 g (0.648 mol) of anhydrous potassium carbonate were suspended in 525 ml of acetonitrile, and, under reflux, 202 g (0.6 mol) of of acetonitrile, and, under reflux, 202 g (0.6 mol) of 1-bromo-3-chloropropyl 4-phenylphenyl ketone were added in portions over 20 minutes. After a reaction time of 3 hours under reflux, the mixture was poured into ice water and the crystals obtained were filtered off under suction. 162.0 g (93% of theory) of colorless crystals of melting point 154°-5° C. were obtained.

Workup

  1. temperatureunder reflux
  2. temperatureAfter a reaction time of 3 hours under reflux
  3. customthe crystals obtained
  4. filtrationwere filtered off under suction
  5. custom162.0 g (93% of theory) of colorless crystals of melting point 154°-5° C. were obtained

Sources & evidence

ORD record
ord-c0576bb4dcea473386e512fd4a1db6a2
Source dataset
uspto-grants-1989_05
Patent number
US04829075

Reaction notes

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