Hydrazine hydrate (1:1) → 4-Chlorophenyl 1-(1, 2, 4-triazol-1-yl)-cyclopropyl ketone hydrazone

HRID 1761892Notes

Reaction equation

HRID 1761892 reaction equation
[N:1]1([C:6]2([C:9]([C:11]3[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=3)=O)[CH2:8][CH2:7]2)[CH:5]=[N:4][CH:3]=[N:2]1.O.[NH2:19][NH2:20]>C(O)C>[N:1]1([C:6]2([C:9](=[N:19][NH2:20])[C:11]3[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=3)[CH2:8][CH2:7]2)[CH:5]=[N:4][CH:3]=[N:2]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 136504511-(4-Chlorobenzoyl)-1-(1,2,4-triazol-1-yl)cyclopropane

Product 1

HCID 867430184-Chlorophenyl 1-(1, 2, 4-triazol-1-yl)-cyclopropyl ketone hydrazoneYield 98%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

37.1 g (0.15 mol) of 4-chlorophenyl 1-(1, 2, 4-triazol-1-yl)-cyclopropyl ketone were refluxed for 6 hours with 37.5 g (0.3 mol) of 80% strength hydrazine hydrate in 150 ml of ethanol. After removing the solvent by distillation in vacuo, 38.5 g (98%) of the title compound were obtained as a yellow oil.

Workup

  1. customAfter removing the solvent
  2. distillationby distillation in vacuo

Sources & evidence

ORD record
ord-6379244c88304b11ba5680509452e2c3
Source dataset
uspto-grants-1989_05
Patent number
US04829075

Reaction notes

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