HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1761902Generated: October 27, 2026
Hydrochloric Acid → 5-Chloro-3-formyl-2-hydroxybenzoic acid
https://huagongshe.com/reaction/1761902
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Hexamethylenetetramine | HCID 4101 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 5-Chlorosalicylic Acid | HCID 9447 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-Chloro-3-formyl-2-hydroxybenzoic acid | HCID 183356 | — |
Reaction Steps
A mixture of 102 g of 5-chloro-2-hydroxybenzoic acid, 166 g of hexamethylenetetramine and 600 ml of trifluoroacetic acid is heated at 100° C. overnight. 2.95 liters of water and 1.48 liters of 10% hydrochloric acid are added to the mixture and said mixture is heated at the same temperature for 15 minutes. After cooling, the resultant crystals are collected by filtration to give 96.9 g of 5-chloro-3-formyl-2-hydroxybenzoic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04829067 |
|---|
| Source dataset | uspto-grants-1989_05 |
|---|
| ORD ID | ord-e707e82c42f946c9892f40a13062b89d |
|---|
| Source note | uspto-grants-1989_05 |
|---|
