Hydrochloric Acid → 5-Chloro-3-formyl-2-hydroxybenzoic acid
Reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:11])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].C1N2CN3CN(C2)CN1C3.FC(F)(F)[C:24](O)=[O:25].Cl>O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:24]=[O:25])[C:5]([OH:11])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8]Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 100 °C
Procedure
A mixture of 102 g of 5-chloro-2-hydroxybenzoic acid, 166 g of hexamethylenetetramine and 600 ml of trifluoroacetic acid is heated at 100° C. overnight. 2.95 liters of water and 1.48 liters of 10% hydrochloric acid are added to the mixture and said mixture is heated at the same temperature for 15 minutes. After cooling, the resultant crystals are collected by filtration to give 96.9 g of 5-chloro-3-formyl-2-hydroxybenzoic acid.
Workup
- temperatureis heated at the same temperature for 15 minutes
- temperatureAfter cooling
- filtrationthe resultant crystals are collected by filtration
Sources & evidence
- ORD record
- ord-e707e82c42f946c9892f40a13062b89d
- Source dataset
- uspto-grants-1989_05
- Patent number
- US04829067
Reaction notes
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