反应详情

A mixture of 2.09 g of (2-methoxycarbonyl-6-formylphenoxy)acetic acid, 1.48 g of sodium acetate and 7 ml of acetic anhydride is refluxed for 1.5 hours. After cooling, water is added to the reaction mixture, and the aqueous mixture is alkalized with potassium carbonate and extracted with ethyl acetate. The extract is washed with water, dried and evaporated to remove solvent. The residue is purified by silica gel column chromatography to give 0.39 g of methyl benzofuran-7-carboxylate as colorless oil.

1. temperatureis refluxed for 1.5 hours
2. temperatureAfter cooling
3. extractionextracted with ethyl acetate
4. washThe extract is washed with water
5. customdried
6. customevaporated
7. customto remove solvent
8. customThe residue is purified by silica gel column chromatography